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Another reason might be changes in blood circulation

Drug Interactions Fluoxetine interacts with several medications, including (22): Monoamine Oxidase Inhibitors Medications that increase serotonin levels Tricyclic antidepressants (TCAs) Lithium Triptan migraine medications Certain opioids Other SSRIs Serotonin and norepinephrine reuptake inhibitors (SNRIs) St Johns Wort Medicines that raise the risk of bleeding Warfarin Apixaban Rivaroxaban Clopidogrel Prasugrel Pimozide and thioridazine Medications metabolized by certain liver enzymes Flecainide Propafenone TCAs Benzodiazepines Antipsychotics Seizures Ask yourself

An early clinical trial in 13 patients with type 2 diabetes found that a single intravenous infusion of 1,000 mg of lipoic acid improved insulin-stimulated glucose disposal (i.e., insulin sensitivity) by 50% compared to a placebo infusion (57)

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This can be particularly beneficial for those suffering from chronic pain or inflammatory diseases