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Oral contraceptive pill efficacy may also be temporarily reduced during semaglutide dose escalation because delayed gastric emptying can lower peak plasma concentrations of orally administered drugs

Thiara and Koliwad, who both prescribe GLP-1s, do this

While GLP-1s are a powerful tool, our focus is on improving your overall metabolic health so youre not dependent long term

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Extrapolation from one study population to another has limits

published third-party studies after GLP-1 withdrawal alone have shown ~10% weight regain at similar time points Upcoming randomized 6-month REMAIN-1 Midpoint Cohort data expected in January 2026