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doi: 10.3390/ani10020342 16 KononovSUMeyerJFrahmJKerstenSKluessJMeyerUet al

We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide