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Novo Nordisk has flagged growing generic competition in markets including India as a potential drag on its international business in 2026, highlighting rising pressure on branded obesity and diabetes therapies as semaglutide loses exclusivity in several countries
Higher doses of dulaglutide (3.0 mg and 4.5 mg) [29] have also received marketing approval for treatment of type 2 diabetes, while application for a label extension of semaglutide at the dose of 2.0 mg [30] has been submitted to the US FDA and has recently received a positive recommendation by the EMA
Some patients on the pill will lose more than the average
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Baseline measurements obtained from the participants determined that 64% of the participants were male, while the mean age was 58 years old, average diabetes duration was approximaely 9 years, the mean HbA1c was recorded at 8.4%, as well as an average body weight of 105.7 kg
Co-crystal structures of GSTO1 with our inhibitors demonstrate covalent binding to the active site cysteine
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