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According to Boehringer Ingelheim, survodutides GLP1 agonism decreases appetite and increases fullness and satiety, while its glucagon agonism is thought to directly act on the liver to reduce hepatic fat, regulate metabolic function, resolve inflammation, and improve fibrosis. The Obesity Medicine Association places survodutide within a broader surge of agents that target both weight and steatotic liver disease

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Researchers said the lower dose was chosen as those with kidney disease can be more sensitive to the effects and side effects of drugs, but it could also allow semaglutide to be more widely used in the wake of its supply limitations

For detailed GLP-1 information, see our tirzepatide dosing guide