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Evidence level: Level A (non-listing) plus plausibility only

Abbreviations ABCG2: ATP-binding cassette transporter G2 Akt: Protein kinase B AMPK: AMP-activated protein kinase BMP4: Bone morphogenetic protein 4 cAMP: Cyclic adenosine monophosphate cas-3: Caspase-3 CDK2: Cyclin-dependent kinase 2 c-Myc: Myelocytomatosis oncogene CRC: Colorectal cancer CREB: CAMP-response element binding protein DPP-4: Dipeptidyl peptidase IV E-cad: E-cadherin ECM: Extracellular matrix EGFR: Epidermal growth factor receptor ENZ: Enzalutamide EMT: Epithelial-mesenchymal transition ERK: Extracellular signal-regulated kinase Ex-4: Exendin-4 FGFR: Fibroblast growth factor receptor GIP: Glucose-dependent Insulinotropic Polypeptide GLP-1: Glucagon-like peptide-1 GLP-1RAs: Glucagon-like peptide-1 receptor agonists GPCR: G-protein-coupled receptor GSK3: Glycogen Synthase Kinase 3 HPV-16E7: Human papillomavirus type 16 E7 protein ICAM-1: Intercellular adhesion molecule-1 IGF: Insulin-like growth factor IL: Interleukin LC3I/II: Microtubule-associated proteins light chain 3I/II LNG-IUD: Levonorgestrel-releasing intrauterine device MAPK: Mitogen-activated protein kinases MMP: Matrix metalloproteinase mTOR: Mammalian target of rapamycin NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis NETs: Neutrophil extracellular traps NF-B: Nuclear factor kappa B PGR: Progesterone receptor PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase PKA: Protein kinase A PSC: Pancreatic stellate cell RCTs: Randomized controlled trials RhoA: Rho-associated kinase ROS: Reactive oxygen species S6K1: Ribosomal s6 kinase 1 SDF-1: Stromal cell-derived factor-1 SGLT2: Sodium-dependent glucose transporters 2 SKP2: S-phase kinase-associated protein-2 STAT3: Signal transducer and activator of transcription 3 T2DM: Type 2 diabetes mellitus TGF-: Transforming growth factor-beta TIMP: Tissue inhibitor of metalloproteinase TNF-: Tumor necrosis factor-alpha TZD: Thiazolidinediones VCAM-1: Vascular cell adhesion molecule-1 VEGF: Vascular endothelial growth factor References Feier CVI, Vonica RC, Faur AM, Streinu DR, Muntean C

For example, recent studies have shown that low doses of semaglutide also have favorable effects on weight management and obesity treatment, making semaglutide a potential anti-obesity drug

Here's What That Might Mean Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on August 18th, 2025

this product is not intended for diagnostic or therapeutic use

Weight interventions improve PsA outcomes PsA treatment guidelines support obesity management in patients with active PsA and obesity GRAPPA recommends maintenance of a healthy weight to improve disease activity and minimize disease impact 8 ACR recommends weight loss for patients with overweight/obesity 15 EULAR recommends that comorbidities such as obesity, metabolic syndrome, cardiovascular disease or depression should be considered managing patients with PsA 16 The modalities of weight management include lifestyle modification (nutrition, physical activity, psychological and behavioral intervention), pharmacotherapy, and bariatric surgery 17-20 Diet-based weight reduction is associated with achievement of MDA in patients with PsA and overweight/obesity starting TNFi therapy 6 5% weight reduction is the major and independent predictor of achieving MDA 6 Odds of achieving MDA increase with higher percent of weight reduction 6 In the DIPSA trial, weight loss magnitude was significantly associated with improvement in clinical outcomes, including DAPSA, pain, fatigue, PsAID, and TJC