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tachyphylaxis Pharmacokinetics: Tyramine is readily metabolized (oxidized) by MAO present in the gastrointestinal endothelium and liver

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Before taking Topiramate, tell your healthcare provider about all of your medical conditions , including if you: Have or have had depression, mood problems, or suicidal thoughts or behavior Have kidney problems, have kidney stones, or are getting kidney dialysis Have a history of metabolic acidosis (too much acid in the blood) Have liver problems Have weak, brittle, or soft bones (osteomalacia, osteoporosis, osteopenia, or decreased bone density) Have lung or breathing problems Have eye problems, especially glaucoma Have diarrhea Have a growth problem Are on a diet high in fat and low in carbohydrates, which is called a ketogenic diet Are having surgery Are pregnant or plan to become pregnant Are breastfeeding or plan to breastfeed

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Lactylation, a recently discovered important form of PTM, plays a key role in various IRI-related diseases, such as myocardial infarction, septic shock, and cerebral IRI [20, 37, 38]