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It can thus affect blood rheology [361]

However, most studies assessing safety issues or toxicity of -tocopherol supplementation have lasted only a few weeks to a few months, and side effects associated with long-term -tocopherol supplementation have not been adequately studied

Most people experience no side effects

Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity

Classical selenium-dependent glutathione peroxidase expression is decreased secondary to iron deficiency in rats