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5 Glucocorticoid-Induced fat metabolism disorder 5.1 Pathogenesis Obesity is a key feature of GC-induced metabolic syndrome [90] and also is a common feature of Cushings syndrome in patients receiving long-term GCs therapy [91, 92]

For many individuals, these effects attenuate over time as physiological adaptation occurs, though some patients continue to experience persistent symptoms throughout treatment

[11] [4] Measurable improvements in serum B12 usually occur within four to eight weeks, though normalisation may take three to six months depending on baseline severity