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For readers interested in exploring related topics at the intersection of addiction, psychiatry, and emerging treatments, I also share additional clinical perspectives and commentary at How Enterhealth Approaches Emerging Treatments At Enterhealth, we closely follow emerging research on GLP-1 medications and addiction, along with other potential advances in neurobiology and pharmacology

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After weight loss: Brain reward circuits become hyperactive in response to food cues Prefrontal cortex inhibitory control becomes less effective Dopamine signaling changes make food more rewarding These changes persist for years, possibly permanently Youre not imagining that food seems more appealing after weight loss

Metabolic Mind

When the medication stops, the biological pressures that caused weight gain in the first place reassert themselves

In some cases, Mounjaro and metformin may be used together