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Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-/SMAD pathway
Functional studies in zebrafish have provided in vivo evidence that disruption of Pgrmc1 (progesterone receptor membrane component 1)a membrane-associated protein that physically interacts with CYP51A1leads to cataract formation, likely due to impaired CYP51A1 activity and dysregulated cholesterol metabolism [48]
Encapsulation efficiency improved substantially, enabling extended experimental timelines
J Headache Pain 22(1):55 Zielman R, Wijnen JP, Webb A et al (2017) Cortical glutamate in migraine
These marks can sometimes last for months or even years
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