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A 2025 review by Mortazavi and Mohammadi Vadoud in BioImpacts flagged skin permeability as the main barrier to translating topical GHK-Cu data into clinical outcomes the compound does not reliably penetrate intact skin at concentrations used in topical products
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The peptide also reduces oxidative stress, which is significantly elevated in psoriatic skin
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For persistent irritation, consider using an over-the-counter cream (preferably with hydrocortisone) or discontinuing use
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