While semaglutide primarily acts on the GLP-1 receptor, retatrutide's triple-agonist approach provides a more comprehensive mechanism, which may provide faster and greater weight loss
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Activation of Killer Immunoglobulin-like Receptor (KIR)-DS1 on uNKs by HLA-C2 on trophoblasts stimulates the production of soluble Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and XCL1 from uNKs leading to increased migration of trophoblasts in vitro (52)
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