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While no formal contraindication exists for concurrent use, the interaction between significant weight loss and hormone levels creates important clinical considerations

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These include inflammatory and autoimmune diseases such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, fibrotic disorders like hepatic, pulmonary, muscle and adipose tissue fibrosis, cancer particularly through TAMs which mediate immunosuppression and facilitate tumor progression and metastasis, metabolic diseases including obesity-associated adipose tissue inflammation, diabetes and its complications, and neurodegenerative conditions such as Alzheimers disease, Parkinsons disease, multiple sclerosis, and stroke, as well as infection ( Figure 4 )