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Heterozygosity at the LDLR locus in classic FH occurs in approximately 1:500 individuals, whereas, homozygosity is observed in approximately 1:1,000,000 individuals

In the treatment arm, the weight loss trajectory over 72 weeks was comparable in both groups: 18.3% weight reduction in MC4R mutation carriers versus 19.9% in noncarriers

Semaglutide's recommended starting dose is 0.25 mg weekly for the first four weeks, and meaningful weight loss typically begins after dose escalation to 1.7 mg or 2.4 mg over 16 to 20 weeks 2

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Evidence-based strategies include consuming protein-rich foods, fermentable fibre (such as oats, legumes, and vegetables), and healthy fats (olive oil, nuts, oily fish)

Mol Aspect Med