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The larger overall reduction in albuminuria in the diabetes (SURMOUNT-2) compared with the nondiabetes (SURMOUNT-1) trial may be explained by the larger proportion of participants with UACR 30 mg/g in SURMOUNT-2

It mimics a hormone naturally occurring in the body that regulates appetite and calorie intake

Side effects are rare but may include nausea, mild headaches, or allergic reactions in some individuals

A separate study also found that curcumin and its oxidative breakdown products boosted GLP-1 release in mice

Orforglipron, while slightly behind in development, could offer better affordability and availability due to simpler manufacturing

CDMO Capex Overshoot