Future research should develop longitudinal datasets to enable analysis of weight loss and side effects in the context of dosage escalations, while exploring genetic factors, which could then inform how genetics might be leveraged in clinical decision-making at treatment initiation and beyond
Ascorbate has the ability to scavange at a greater percentage to GSH, therefore increased doses of ascorbate will see the sparing of GSH in the cell improving cellular performace of GSH
The theory: lipotropic agents support liver function in metabolizing stored fat, while B12 addresses the fatigue that often accompanies caloric restriction
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References Cheles D, Vinshtok Y, Gershonowitz A
Cycling off and monitoring response is a smart strategy before reintroducing the compound again