Taken together, these findings suggest that greater weight reduction during the pre-landmark period did not correlate with reduced rates of newly documented cardiovascular outcomes in the post-landmark period
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Adding GIP (the dual-agonist tirzepatide step) meaningfully amplifies the satiety and adipose-tissue effects beyond what GLP-1-only molecules achieve, despite earlier scepticism that GIP signalling was non-functional in type-2 diabetes
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