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This happens because medications don't address why your body isn't producing enough GLP-1 naturally

Arbutin, the b-D-glucopyranoside derivative of hydroquinone, is a naturally occurring plant-derived compound found in the dried leaves of a number of different plant species including, bearberry (Arctostaphylos uva-ursi), blueberry, cranberry, and pear trees

Nature (1993) 361:319

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My personal protocol to keep my periods regular is eating for blood sugar balance, eating a high-protein diet, taking thyroid meds on an empty stomach, reducing caffeine intake (no more than three cups of black tea per day), taking two capsules per day of MTHFR Pathways , taking 2000 mg of myo-inositol per day (which is actually closer to a PCOS dose of myo-inositol than the Hashimotos dose of 600 mg), and trying Beeya seed cycling