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It is however important to note that human clinical trials are still limited and side effects, as above, have been reported
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Always verify current clinical-trial and regulatory status through primary sources such as ClinicalTrials.gov, PubMed, and the FDA.
Oncotarget (2017) 8(65):10841829
Ice crystal formation physically disrupts peptide bonds with each cycle
Moreover, baseline LBP and sCD14 levels were similar in patients with normal (2/3 of patients) and increased intestinal permeability (urinary 51 Cr-EDTA excretion), highlighting again that bacterial translocation is not a paracellular phenomenon and that one should be careful of connecting clinical outcomes to paracellular permeability tests (149)
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