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GLP-1 also helps moderate other hormones related to blood sugar and appetite, including leptin, which signals fullness, and ghrelin, the hunger hormone. Additionally, GLP-1 slows gastric emptying, which sustains a feeling of fullness and decreases the speed at which glucose enters the bloodstream
Patients should be aware that the appetite suppression is medication-dependent
12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)
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