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Enzymes governing glycolytic flux in CRC cells exhibit crosstalk with TME dynamics, while EMP inhibitors demonstrate potential to mitigate treatment resistance to radiotherapy and chemotherapy

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Insulin also exerts important direct effects on the microvasculature, causing vasodilatation and reversing the endothelial dysfunction commonly seen in T2DM [45]

pylori infection directly causes oxidative stress in gastric epithelial cells by the production of ROS, and it also stimulates host responses that result in ROS and controls the production of proinflammatory cytokines, inflammation, and cell death (99)

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Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment