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Secondary signals across both trials reduced knee osteoarthritis pain, fewer obstructive sleep apnea events, improvements in triglycerides, blood pressure, LDL, and hsCRP suggest systemic metabolic remodeling rather than simple caloric suppression
Semaglutide and tirzepatide are not recommended in patients with severe gastroparesis (when the stomach empties food into the small intestine too slowly)
Addressing iron status early prevents energy crashes that can derail adherence to your GLP-1 therapy
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