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By controlling appetite and improving insulin sensitivity, the therapy supports several beneficial outcomes: Reduced portion sizes and improved satiety Lower caloric intake without excessive hunger Improved glycaemic control in patients with insulin resistance or metabolic syndrome Favourable body-composition changes , with a higher ratio of fat loss to lean mass loss Improved cardiometabolic markers , including cholesterol and blood pressure Clinical studies have shown that individuals on GLP-1 receptor agonist therapy can experience significant reductions in body weight over time when combined with dietary adjustments and physical activity

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Wegovy (semaglutide) works similarly, but is at a higher dose

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And the National Institute of Health recognizes that bariatric surgery is the only effective treatment for long-term weight loss for those patients who have had no previous success with the traditional approaches of diet and exercise