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Pairing semaglutide with other treatments could enhance its effectiveness

Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester were sequentially coupled by conventional amino acid coupling

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Specific examples include: (1) pramlintide (amylin analog), which received FDA approval only after evidence standards shifted to accommodate an injectable adjunct therapy, having initially faced barriers related to delivery format and market positioning