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Lancet (London, England), 397(10278), 971984

Drug Interactions The concomitant use of JANUMET XR with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see Drug Interactions (7)]

doi: 10.1002/jnr.23335 220 GaoCLiuYJiangYDingJLiL

3 nmol/kg dose: PBS/PBS, n = 7

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