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For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

doi: 10.1530/eje-12-1037 30 CopinschiGNedeltchevaALeproultRMorselliLLSpiegelKMartinoEet al

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The time point introducing a well-balanced Paleolithic diet may be a special issue of concern as proper IIS is important for the function of the reproductive and central nervous system

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A study investigating the effects of thrice-weekly moderate intensity resistance-band RT with self-directed intensity progression in over 200 community dwelling older adults demonstrated marked improvements in working memory (Lachman et al., 2006)