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In the long term, weight change itself is meaningful: clinical trials, the Weight Loss Study, found that semaglutide can reduce body weight by an average of 10% over 68 weeks, which helps explain why lipid and glucose levels often change

Heart rate is also phenotype-coupled: near zero at 1 mg in the obese trial cohort, but +10 bpm or more at the same 1 mg in a leaner body from Phase 1

GLP-1 medications offer many potential benefits, such as weight loss, type 2 diabetes management, and lower blood pressure

Increased doses come with an upcharge of $100/month

GLP-1 medications work differently

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