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They know increased glutathione can cause drug resistance by binding or reacting to the drugs, preventing damage to proteins or DNA, or helping repair DNA all these would keep the chemo agents from hurting the cancer cells

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Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site

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