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The above leads to the overproduction of ROS and RNS, and it intensifies cytokine and chemokine secretion via a positive feedback loop (174)

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Approximate 80% drug release was observed within 12 h at pH 5.0 due to the synergetic effect of hydrolysis of cis-aconityl linkage leading to charge reversal of cis-aconityl functionalized DOX and further protonation of PEG-acrylate copolymer

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