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At room temperature (2025C), reconstituted Melanotan-2 loses approximately 1015% potency per week through hydrolysis and oxidation reactions

This delayed gastric emptying is precisely how the drug creates a sustained sense of fullness and reduces appetite

The histopathological lesion scores in Supplementary Table 5 indicate that the most severe adverse effects (75100%) were observed in the cerebral cortex of all treated groups

We needed to design a new molecule that could both get across the intestinal epithelium and would also be resistant to those peptidases [the DPP-4 enzyme] we talked about

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