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PMCID: PMC6389332

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Interestingly, PF protected H 2 O 2 -induced PIG1 and PIG3V cells from oxidative stress by activating JNK/Nrf2/HO-1 signaling pathway, including decreased ROS level and increased SOD, CAT, Nrf2 and HO-1 expression

The goal is not to use the most medication possible

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Comparison with structures of the AMY 1 R bound to non-lipidated peptides (CagriBB and rAmy) revealed that the lipid conjugation does not affect the conformation of the peptide, nor the receptor when Cagri is stably engaged