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There have been a number of systematic reviews/meta-analyses of controlled trials of selenium treatment in patients with AITD/HT ( Reference Schomburg 70 , Reference Wichman, Bonnema and Hegedus 88 Reference Fan, Xu and Zhang 90 )

Summary : Vitamin B12 is naturally occurring in a variety of animal-based foods

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Further, MTX increased the expression of PERK (Figure 6B), GRP78 (Figure 6C), ATF4 (Figure 6D), and CHOP-10 (Figure 6E) in the liver compared to CTRL, indicating that ER stress is implicated in MTX-induced hepatotoxicity