Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus a systematic review and meta-analysis of randomized control trials
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Platelet-derived growth factor PDGF-AA upregulates connexin 43 expression and promotes gap junction formations in osteoblast cells through p-Akt signaling
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The GLP-1 component promotes insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite effects well established across the GLP-1 drug class
Studies suggest side effects can occur in 40-70% of patients receiving a GLP-1 RA