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Microdialysis experiments showed that tirzepatide diminished alcohol-evoked dopamine release in the nucleus accumbens, as well as associated dopamine metabolites, while having no effect on baseline dopamine levels

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When to contact a healthcare provider Most aches and pains on Zepbound are mild and manageable

Other adverse effects of hydrocodone include: Respiratory: severe respiratory depression, shortness of breath Cardiovascular: hypotension, bradycardia, peripheral edema Neurologic: Headache, chills, anxiety, sedation, insomnia, dizziness, drowsiness, fatigue Dermatologic: Pruritus, diaphoresis, rash Gastrointestinal: Vomiting, dyspepsia, gastroenteritis, abdominal pain Genitourinary: Urinary tract infection, urinary retention Otic: Tinnitus, sensorineural hearing loss Endocrine: Secondary adrenal insufficiency (17) Hydrocodone acts as an agonist and can cause sedation and respiratory depression when combined with other central nervous system depressants, so patients must not take it with those agents (53)

Pavlakis, S