This imbalance disrupts normal protein metabolism
Owing to the rapid degradation of GLP-1 by dipeptidyl peptidase type 4 (DPP-4), it is structurally modified into more stable GLP-1R agonists, such as liraglutide, exenatide, and dulaglutide, which share 97%, 53%, and 90% sequence homology, respectively 12
This is significantly higher than standard recommendations and often requires protein supplementation to achieve
When someone begins GLP-1 therapy, appetite suppression and reduced calorie intake can trigger muscle loss alongside fat lossa concern that makes creatine supplementation seem beneficial
However, the comparability of such studies depends heavily on the definition of washout periods, follow-up windows, and pregnancy criteria (110)
How May the Program Support Weight Management