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This prolonged retention increases pressure, fullness, and discomfort, especially after larger, protein-dense, or high-fat meals, even though digestion continues normally and food is not physically blocked. Large meal volume and gastric distension Larger meal volumes cause the stomach to stretch

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Yes, the purging phase with tretinoin can last up to three months as it accelerates skin cell turnover, bringing underlying impurities to the surface before the skin improves and stabilizes

Similarly, deleting GLP-1Rs in the VMH does not prevent the inhibitory effects of chronic systemic exendin-4 and liraglutide on food intake and body weight [132]