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Selenium without sufficient glutathione cannot fully activate GPx - making glutathione and selenium complementary, synergistic interventions for thyroid autoimmunity

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For example, cysteine is the limiting amino acid in GSH synthesis, and inhibiting its import through the cystine/glutamate antiporter SLC7A11 is sufficient to induce ferroptosis by depleting GSH levels [22]

Brattstrm L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, and Hamfelt A (1992)

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That's where "liposomal" glutathione comes in