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A study on genetic linkages between aberrant lipid metabolism and PD directly demonstrates that glucocerebrosidase and sphingomyelin phosphodiesterase 1 mutations enhance PD risk in humans, and that galactosylceramide beta hydrolase function loss increases -synuclein aggregation and accumulation in experimental murine models
The complete conservation of GLP-1 across all mammalian species underscores its critical physiological role (29, 30) [ Figure 2 ]
AOD 9604 promotes lipolysis (fat breakdown), and inhibits lipogenesis (the formation of new fat)
doi.org/10.3389/fphar.2021.627533 Chang, C
SURMOUNT-1 Trial (Jastreboff et al., 2022): Even at the 2.5 mg starting dose, participants achieved 16% weight loss
So, while Ozempic may (STILL) not have received the FDA's seal of approval for weight loss in non-diabetic patients, its hidden talent paved the way for Wegovy to step into the spotlight and take on a leading role in weight management
