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Similar to the story of GLP-1 drugs, the weight loss effects of targeting glucagon and GIP could have only been achieved with drugs that could chronically activate hormone receptors across the body, drugs with effects that are more potent and widespread in the body than the natural hormones that are secreted

Semaglutide and Beyond: A Turning Point in Obesity Pharmacotherapy

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For individuals with a body mass index (BMI) of 30 kg/m or above (or 27.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds), NICE recommends considering pharmacological interventions alongside lifestyle changes when dietary and exercise modifications alone have been insufficient

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