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Retatrutide is an investigational triple-agonist (GLP-1, GIP, and glucagon) with a half-life of roughly 6 days (Coskun et al., Cell Metabolism, 2022)
C., Colhoun, H
Ozempic is about 95 per cent similar to natural GLP-1, but the small differences make it easier for it to bind to carriers in the blood and harder for it to be broken down
Some people use it short-term, while others stay on it longer to help manage weight or blood sugar
Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero J-J, Chan W, et al
or 24 kg on 15 mg), compared to placebo (2.4%, 5 lb
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