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Because these products are unregulated supplements rather than medical-grade treatments, the risks range from minor skin irritation to more serious systemic issues caused by hidden or potent ingredients
Effects of Tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data
The effect builds up slowly
More serious but less common adverse effects require careful monitoring
The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors
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