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Evidence on B12 Supplementation During GLP-1 Therapy Clinical trials of semaglutide for weight loss (the STEP trials with over 4,500 participants) did not routinely pair semaglutide with B12 injections or measure specific B12 supplementation outcomes

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proper injection technique and site rotation can minimize these local reactions, and they tend to resolve quickly on their own

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160-200 pounds (72-90kg): The standard 400mcg daily protocol works well for most individuals in this range