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We additionally summarize the evidence by domain and certainty level in a structured Supplementary Table 6, explicitly separating relatively robust short-term metabolic evidence from more exploratory reproductive and periconception safety findings

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Retatrutide (LY3437943) is a single peptide engineered to agonise three incretin-family receptors at once: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR) 26