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A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care
No controlled GLOW trial establishes a results timeline
Also, the following risk factors can increase the chance of developing vitamin B-12 deficiency: Alcohol abuse Smoking Certain prescription medications, including antacids and some type 2 diabetes drugs Having an endocrine-related autoimmune disorder, such as diabetes or a thyroid disorder Eating a vegetarian or vegan diet Certain gastrointestinal disorders, such as crohns disease Gastric bypass or the removal of parts of the stomach Aging Benefits of B-12 Shots There are several reasons to consider getting a B-12 shot, including: Reduced risk of vitamin B-12 deficiency and associated complications The most obvious benefit of receiving vitamin B-12 shots is treating a vitamin B-12 deficiency and avoiding its associated symptoms
In rare situations, B12 shots itching rash anaphylaxis, a life threatening condition that can cause a fast heartbeat and difficulty breathing Other side effects that can occur include: shortness of breath, fast weight gain, and swelling congestive heart failure, the inability of the heart to adequately pump blood pulmonary edema, the buildup of fluid in the lungs peripheral vascular thrombosis, the obstruction of a vein with a blood clot hypokalemia, low potassium levels that can cause irregular heartbeats and muscle weakness fever tingling, numbness, and joint pain swollen tongue polycythemia, an increase in the red blood cell mass Additionally, B12 B12 shots are not necessary for weight loss
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