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39,44,47 In one crossover study, 47 homocysteine levels returned to baseline when NAC was stopped for the 1-month washout period, suggesting that effects are immediate and that NAC may need to be taken continuously to help maintain homocysteine levels

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The field currently lacks the application of standardized approaches for microbiota modulation, like FMT and precision nutrition, which further hinder reproducibility and clinical application (Lu et al., 2024)