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In a trial of WEGOVY injection in adult patients with type 2 diabetes and body mass index (BMI) greater than or equal to 27 kg/m2 for weight reduction (Study 3), hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in more patients treated with WEGOVY versus placebo [see Adverse Reactions (6.1)]

The modified CT Severity Index (CTSI) scores help stratify patients, with scores above 8 indicating severe disease with mortality rates approaching 20% and high likelihood of permanent complications

However, it is important to note that samples may have to be produced for submission of product registration

however, any potential symptomatic benefits may simply be due to weight loss

Increased catabolism leads to low plasma glutamine and is associated with low albumin levels, triggering severe inflammation and malnutrition

PMCID: PMC4328900