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Prelamin A and subsequently mature Lamin A/C protein constitutes the nuclear lamina and nuclear matrix, and involves in a variety of nuclear activities to keep cellular stability and activity 22,23,24

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[CrossRef] [Google Scholar] Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies

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In exploratory random-effects (REML) meta-regression based on the primary pooled dataset, neither treatment duration nor ALC daily dose showed a clear association with the standardized treatment effect