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placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial

Examples are MTHFR variants, which impact folate metabolism and homocysteine, FTO and MC4R, which are associated with weight regulation, CYP19A1, which is involved in aromatase and estrogen balance, ESR1 and ESR2, which are estrogen receptors, and variants in FSHR and LHCGR that alter ovarian response

But the Phase 2 curve suggests total weight loss could reach 20 to 25% of body weight at peak effect for the highest dose group

PlexusDx's Precision Peptide Genetic Test analyzes key variants like GIPR rs1800437 to reveal how your genetic makeup influences medication response

While all of these medications are designed to promote weight loss, they work in different ways and have different dosing schedules

doi: 10.1016/S0140-6736(23)01200-X