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doi: 10.1002/rmv.2221 200 MuraeM.ShimizuY.YamamotoY.KobayashiA.HouriM.InoueT.et al

Growth factors and signalling molecules modulate the melanin synthesis pathway, reducing tyrosinase activity and melanin transfer to keratinocytes the fundamental mechanism driving pigmentation

Our findings build on previous research showing high discontinuation rates, particularly among individuals using GLP-1 RAs for weight management ( 10 ), and provide new insights into how and why these medications are stopped in real-world clinical settings

All protocols require informed consent, medical oversight, and realistic expectations about potential outcomes

Once the immediate deficiency is corrected, the frequency is reduced to weekly and eventually monthly sessions

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